If you’ve tried antidepressants, talk therapy, or both–and still find yourself stuck in a cycle of depression–there is hope. At Urgent Care Plus & Wellness, we offer Ketamine Infusion Therapy as an innovative, science-backed option for treatment-resistant depression. Our infusions are administered in a safe, private clinical setting under the direct supervision of Dr. Luke Afuwape, a board-certified Emergency Medicine physician with over 15 years of experience. Many patients experience significant improvement in mood, outlook, and function after just a few ketamine sessions–even when other treatments haven’t worked.
I am giving 5 stars because Dr Luke and his team were so professional and caring. I loved the ambience of the clinic, and there was no wait time. Dr. Luke took his time to Iisten to our complaints and concerns. Big thanks to the team at Urgent Care Plus and Wellness.
How Ketamine Therapy Works for Depression
Ketamine is not a traditional antidepressant–it works in a completely different way than SSRIs, SNRIs, or other commonly prescribed medications. Originally developed as an anesthetic, ketamine has since been studied extensively for its rapid antidepressant effects, particularly in individuals with treatment-resistant depression (TRD)–those who haven’t responded to two or more standard treatments.
Ketamine acts on the brain’s glutamate system, rather than serotonin. Specifically, it blocks NMDA receptors and increases levels of glutamate, a key neurotransmitter involved in learning, memory, and mood regulation. This activity stimulates the release of brain-derived neurotrophic factor (BDNF) and promotes the formation of new synaptic connections–essentially helping the brain “rewire” itself and recover from the effects of prolonged stress and trauma.
What Makes Ketamine Therapy Different?
Rapid Relief
Many patients begin to feel a reduction in depressive symptoms within hours to a few days after their first infusion.
Effective for Suicidal Thoughts
Ketamine is one of the most effective tools for reducing suicidal ideation, often within a single session.
Neuroplasticity
It promotes the brain’s ability to heal, adapt, and rebuild.
Improved Treatment Response
Ketamine can enhance the effectiveness of talk therapy or medications that previously failed.
A Science-Backed Treatment Plan, Designed for You
At Urgent Care Plus & Wellness, ketamine is not used as a one-size-fits-all solution. Each patient undergoes a thorough consultation with Dr. Luke, who reviews your mental health history, current medications, lab work (if available), and past treatment response. From there, we develop a personalized infusion protocol, adjusting dose and frequency to match your needs and safety profile.
You’re supported every step of the way–physically, emotionally, and medically.
What to Expect During Your Visit
Each session typically lasts 40-60 minutes in a quiet, private room. You’ll be monitored by our trained medical staff and have access to Dr. Luke throughout the process. Many patients begin to feel relief within hours to a few days after their initial infusions.
We also provide guidance for follow-up care, booster infusions, and referrals to therapists or mental health specialists as needed.
About UsKetamine Therapy for Depression–Find Relief in Richmond, TX
When traditional treatments haven’t worked, Ketamine Therapy may offer new hope. At Urgent Care Plus & Wellness, we provide physician-guided ketamine infusions in a calm, supportive environment–designed to help you regain control and feel like yourself again. Contact us today to schedule a consultation or learn more. Conveniently located in Richmond, we proudly serve Katy, Aliana, Grand Mission, Sugar Land, and surrounding West Houston communities.
